Adami, C., Spadavecchia, C., 2020. Use of nociceptive threshold testing in cats in experimental and clinical settings: a qualitative review. Veterinary Anaesthesia and Analgesia 47, 419–436. https://doi.org/10.1016/j.vaa.2019.12.009
Amorim, I., Taulescu, M.A., Day, M.J., Catoi, C., Reis, C.A., Carneiro, F., Gärtner, F., 2016. Canine Gastric Pathology: A Review. Journal of Comparative Pathology 154, 9–37. https://doi.org/10.1016/j.jcpa.2015.10.181
Aragon, C.L., Hofmeister, E.H., Budsberg, S.C., 2007. Systematic review of clinical trials of treatments for osteoarthritis in dogs. J Am Vet Med Assoc 230, 514–521. https://doi.org/10.2460/javma.230.4.514
Arculus, S.L., 2004. Use of meloxicam as an analgesic in canine orthopaedic surgery. Vet Rec 155, 784.
Baetge, C.L., Matthews, N.S., 2012. Anesthesia and Analgesia for Geriatric Veterinary Patients. Veterinary Clinics of North America: Small Animal Practice, Geriatrics 42, 643–653. https://doi.org/10.1016/j.cvsm.2012.05.001
Bardagí, M., Fondevila, D., Ferrer, L., 2012. Immunohistochemical detection of COX-2 in feline and canine actinic keratoses and cutaneous squamous cell carcinoma. J Comp Pathol 146, 11–17. https://doi.org/10.1016/j.jcpa.2011.03.012
Battersby, I.A., Murphy, K.F., Tasker, S., Papasouliotis, K., 2006. Retrospective study of fever in dogs: laboratory testing, diagnoses and influence of prior treatment. J Small Anim Pract 47, 370–376. https://doi.org/10.1111/j.1748-5827.2006.00042.x
Beale, B.S., 2005. Orthopedic Problems in Geriatric Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice, Geriatrics 35, 655–674. https://doi.org/10.1016/j.cvsm.2005.01.001
Beckman, B., 2013. Anesthesia and Pain Management for Small Animals. Veterinary Clinics of North America: Small Animal Practice, Clinical Veterinary Dentistry 43, 669–688. https://doi.org/10.1016/j.cvsm.2013.02.006
Belshaw, Z., Dean, R., Asher, L., 2020. Could it be osteoarthritis? How dog owners and veterinary surgeons describe identifying canine osteoarthritis in a general practice setting. Preventive Veterinary Medicine 185, 105198. https://doi.org/10.1016/j.prevetmed.2020.105198
Bendinelli, C., Properzi, R., Boschi, P., Bresciani, C., Rocca, E., Sabbioni, A., Leonardi, F., 2019. Meloxicam vs robenacoxib for postoperative pain management in dogs undergoing combined laparoscopic ovariectomy and laparoscopic-assisted gastropexy. Vet Surg 48, 578–583. https://doi.org/10.1111/vsu.13156
Bennett, C., Cook, N., 2019. Palliative Care Services at Home: Viewpoint from a Multidoctor Practice. Veterinary Clinics of North America: Small Animal Practice, Advances in Palliative Medicine 49, 529–551. https://doi.org/10.1016/j.cvsm.2019.01.018
Berry, S.H., 2015. Analgesia in the Perioperative Period. Veterinary Clinics of North America: Small Animal Practice, Perioperative Care 45, 1013–1027. https://doi.org/10.1016/j.cvsm.2015.04.007
Blois, S.L., Allen, D.G., Wood, R.D., Conlon, P.D., 2010. Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs. Am. J. Vet. Res. 71, 349–358. https://doi.org/10.2460/ajvr.71.3.349
Borer, L.R., Peel, J.E., Seewald, W., Schawalder, P., Spreng, D.E., 2003. Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. Am J Vet Res 64, 1429–1437. https://doi.org/10.2460/ajvr.2003.64.1429
Borges, M., Marini Filho, R., Laposy, C.B., Guimarães-Okamoto, P.T.C., Chaves, M.P., Vieira, A.N.L.S., Melchert, A., 2013. Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs. Acta Cir Bras 28, 842–847. https://doi.org/10.1590/s0102-86502013001200006
Boston, S.E., Moens, N.M.M., Kruth, S.A., Southorn, E.P., 2003. Endoscopic evaluation of the gastroduodenal mucosa to determine the safety of short-term concurrent administration of meloxicam and dexamethasone in healthy dogs. Am J Vet Res 64, 1369–1375. https://doi.org/10.2460/ajvr.2003.64.1369
Boström, I.M., Nyman, G., Hoppe, A., Lord, P., 2006. Effects of meloxicam on renal function in dogs with hypotension during anaesthesia. Vet Anaesth Analg 33, 62–69. https://doi.org/10.1111/j.1467-2995.2005.00208.x
Bradbrook, C., Clark, L., 2018. State of the art analgesia—Recent developments pharmacological approaches to acute pain management in dogs and cats: Part 2. The Veterinary Journal 236, 62–67. https://doi.org/10.1016/j.tvjl.2018.04.009
Bradbrook, C.A., Clark, L., 2018. State of the art analgesia- recent developments in pharmacological approaches to acute pain management in dogs and cats. Part 1. The Veterinary Journal 238, 76–82. https://doi.org/10.1016/j.tvjl.2018.06.003
Brideau, C., Van Staden, C., Chan, C.C., 2001. In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats. Am J Vet Res 62, 1755–1760. https://doi.org/10.2460/ajvr.2001.62.1755
Brydges, N.M., Argyle, D.J., Mosley, J.R., Duncan, J.C., Fleetwood-Walker, S., Clements, D.N., 2012. Clinical assessments of increased sensory sensitivity in dogs with cranial cruciate ligament rupture. The Veterinary Journal 193, 545–550. https://doi.org/10.1016/j.tvjl.2012.01.019
Budsberg, S.C., Cross, A.R., Quandt, J.E., Pablo, L.S., Runk, A.R., 2002. Evaluation of intravenous administration of meloxicam for perioperative pain management following stifle joint surgery in dogs. Am J Vet Res 63, 1557–1563. https://doi.org/10.2460/ajvr.2002.63.1557
Burian, M., Geisslinger, G., 2005. COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites. Pharmacology & Therapeutics 107, 139–154. https://doi.org/10.1016/j.pharmthera.2005.02.004
Busch, U., Schmid, J., Heinzel, G., Schmaus, H., Baierl, J., Huber, C., Roth, W., 1998. Pharmacokinetics of meloxicam in animals and the relevance to humans. Drug Metab. Dispos. 26, 576–584.
Butterton, S., 2013. NSAIDs in the treatment of polyuria and polydipsia in dogs. Vet Rec 173, 352. https://doi.org/10.1136/vr.f6084
Cannon, C.M., Allstadt, S.D., 2015. Lower Urinary Tract Cancer. Veterinary Clinics of North America: Small Animal Practice, Urology 45, 807–824. https://doi.org/10.1016/j.cvsm.2015.02.008
Cary, C.D., Lukovsky-Akhsanov, N.L., Gallardo-Romero, N.F., Tansey, C.M., Ostergaard, S.D., Taylor, W.D., Morgan, C.N., Powell, N., Lathrop, G.W., Hutson, C.L., 2017. Pharmacokinetic Profiles of Meloxicam and Sustained-release Buprenorphine in Prairie Dogs (Cynomys ludovicianus). J Am Assoc Lab Anim Sci 56, 160–165.
Catanzaro, A., Di Salvo, A., Steagall, P.V., Zampini, D., Polisca, A., della Rocca, G., 2016. Preliminary study on attitudes, opinions and knowledge of Italian veterinarians with regard to abdominal visceral pain in dogs. Veterinary Anaesthesia and Analgesia 43, 361–370. https://doi.org/10.1111/vaa.12326
Caulkett, N., Read, M., Fowler, D., Waldner, C., 2003. A comparison of the analgesic effects of butorphanol with those of meloxicam after elective ovariohysterectomy in dogs. Can Vet J 44, 565–570.
Caulkett, N., Read, M., Fowler, D., Waldner, C., 2002. The analgesic effects of butorphanol and meloxicam after elective ovariohysterectomy in dogs. Vet Anaesth Analg 29, 103. https://doi.org/10.1046/j.1467-2995.2002.00078_16.x
Cerda-Gonzalez, S., Dewey, C.W., 2010. Congenital Diseases of the Craniocervical Junction in the Dog. Veterinary Clinics of North America: Small Animal Practice, Diseases of the Brain 40, 121–141. https://doi.org/10.1016/j.cvsm.2009.10.001
Charlier, C., Michaux, C., 2003. Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs. European Journal of Medicinal Chemistry 38, 645–659. https://doi.org/10.1016/S0223-5234(03)00115-6
Chervier, C., Chabanne, L., Godde, M., Rodriguez-Piñeiro, M.I., Deputte, B.L., Cadoré, J.-L., 2012. Causes, diagnostic signs, and the utility of investigations of fever in dogs: 50 cases. Can Vet J 53, 525–530.
Chohan, A.S., 2010. Anesthetic Considerations in Orthopedic Patients With or Without Trauma. Topics in Companion Animal Medicine, Anesthesia Update 25, 107–119. https://doi.org/10.1053/j.tcam.2010.01.002
Clark, T.P., 2006. The Clinical Pharmacology of Cyclooxygenase-2–Selective and Dual Inhibitors. Veterinary Clinics of North America: Small Animal Practice, Current Topics in Clinical Pharmacology and Therapeutics 36, 1061–1085. https://doi.org/10.1016/j.cvsm.2006.07.001
Cozzi, E.M., Spensley, M.S., 2013. Multicenter randomized prospective clinical evaluation of meloxicam administered via transmucosal oral spray in client-owned dogs. J Vet Pharmacol Ther 36, 609–616. https://doi.org/10.1111/jvp.12050
Crandell, D.E., Mathews, K.A., Dyson, D.H., 2004. Effect of meloxicam and carprofen on renal function when administered to healthy dogs prior to anesthesia and painful stimulation. Am J Vet Res 65, 1384–1390. https://doi.org/10.2460/ajvr.2004.65.1384
Cunningham, F.M., Lees, P., 1994. Advances in anti-inflammatory therapy. British Veterinary Journal 150, 115–134. https://doi.org/10.1016/S0007-1935(05)80221-0
da Costa, R.C., 2010. Cervical Spondylomyelopathy (Wobbler Syndrome) in Dogs. Veterinary Clinics of North America: Small Animal Practice, Spinal Diseases 40, 881–913. https://doi.org/10.1016/j.cvsm.2010.06.003
Davidson, J.R., Kerwin, S.C., Millis, D.L., 2005. Rehabilitation for the Orthopedic Patient. Veterinary Clinics of North America: Small Animal Practice, Rehabilitation and Physical Therapy 35, 1357–1388. https://doi.org/10.1016/j.cvsm.2005.08.006
Deneuche, A.J., Dufayet, C., Goby, L., Fayolle, P., Desbois, C., 2004. Analgesic comparison of meloxicam or ketoprofen for orthopedic surgery in dogs. Vet Surg 33, 650–660. https://doi.org/10.1111/j.1532-950X.2004.04088.x
Di Salvo, A., Chiaradia, E., Nannarone, S., della Rocca, G., 2021. Intra-articular use of analgesic/antinflammatory drugs in dogs and horses. Research in Veterinary Science 134, 159–170. https://doi.org/10.1016/j.rvsc.2020.12.014
Doig, P.A., Purbrick, K.A., Hare, J.E., McKeown, D.B., 2000. Clinical efficacy and tolerance of meloxicam in dogs with chronic osteoarthritis. Can Vet J 41, 296–300.
Doit, H., Wareham, K., 2016. Can you reduce the dose of meloxicam in dogs with osteoarthritis? Vet Rec 179, 600–601. https://doi.org/10.1136/vr.i5692
Downing, R., 2011. Pain Management for Veterinary Palliative Care and Hospice Patients. Veterinary Clinics of North America: Small Animal Practice, Palliative Medicine and Hospice Care 41, 531–550. https://doi.org/10.1016/j.cvsm.2011.03.010
Engelhardt, G., Homma, D., Schlegel, K., Utzmann, R., Schnitzler, C., 1995. Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance. Inflamm Res 44, 423–433. https://doi.org/10.1007/BF01757699
Eskafian, H., Shojaee Tabrizi, A., Ansari Lari, M., 2017. Gastroscopic Study of Meloxicam, Tramadol, and Their Combined Administration on the Development of Gastric Injuries in Dogs. Top Companion Anim Med 32, 109–113. https://doi.org/10.1053/j.tcam.2017.09.001
Fletcher, J.R., 1982. The role of prostaglandins in sepsis. Scand J Infect Dis Suppl 31, 55–60.
Forsyth, S.F., Guilford, W.G., Haslett, S.J., Godfrey, J., 1998. Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs. J Small Anim Pract 39, 421–424. https://doi.org/10.1111/j.1748-5827.1998.tb03748.x
Fowler, D., Isakow, K., Caulkett, N., Waldner, C., 2003. An evaluation of the analgesic effects of meloxicam in addition to epidural morphine/mepivacaine in dogs undergoing cranial cruciate ligament repair. Can Vet J 44, 643–648.
Frank, D., 2014. Recognizing Behavioral Signs of Pain and Disease: A Guide for Practitioners. Veterinary Clinics of North America: Small Animal Practice, Behavior: A Guide for Practitioners 44, 507–524. https://doi.org/10.1016/j.cvsm.2014.01.002
Fusellier, M., Desfontis, J.-C., Le Roux, A., Madec, S., Gautier, F., Thuleau, A., Gogny, M., 2008. Effect of short-term treatment with meloxicam and pimobendan on the renal function in healthy beagle dogs. J Vet Pharmacol Ther 31, 150–155. https://doi.org/10.1111/j.1365-2885.2007.00934.x
Gagnon, A., Brown, D., Moreau, M., Lussier, B., Otis, C., Troncy, E., 2017. Therapeutic response analysis in dogs with naturally occurring osteoarthritis. Veterinary Anaesthesia and Analgesia 44, 1373–1381. https://doi.org/10.1016/j.vaa.2017.07.008
Gassner, G., Stephan, I., Schütt-Mast, I., 1998. [Observations on the side effects after application of non-steroidal anti-inflammatory agents in dogs]. Tierarztl Prax Ausg K Kleintiere Heimtiere 26, 119–123.
Gaynor, J.S., 2008. Control of Cancer Pain in Veterinary Patients. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1429–1448. https://doi.org/10.1016/j.cvsm.2008.06.009
Giuliano, E.A., 2004. Nonsteroidal anti-inflammatory drugs in veterinary ophthalmology. Veterinary Clinics of North America: Small Animal Practice, Ocular Therapeutics 34, 707–723. https://doi.org/10.1016/j.cvsm.2003.12.003
Gower, S., 2018. Meloxicam in racing greyhounds. Vet Rec 182, 518. https://doi.org/10.1136/vr.k1914
Guerin, V.J., ’t Hooft, K.W.V., L’Eplattenier, H.F., Petite, A.F., 2012. Transitional cell carcinoma involving the ductus deferens in a dog. J Am Vet Med Assoc 240, 446–449. https://doi.org/10.2460/javma.240.4.446
Gunew, M.N., Menrath, V.H., Marshall, R.D., 2008. Long-term safety, efficacy and palatability of oral meloxicam at 0.01-0.03 mg/kg for treatment of osteoarthritic pain in cats. J Feline Med Surg 10, 235–241. https://doi.org/10.1016/j.jfms.2007.10.007
Hansen, B., 2000. Acute Pain Management. Veterinary Clinics of North America: Small Animal Practice 30, 899–916. https://doi.org/10.1016/S0195-5616(08)70014-7
Hare, J.E., Niemuller, C.A., Petrick, D.M., 2013. Target animal safety study of meloxicam administered via transmucosal oral spray (Promist(®) technology) for 6 months in dogs. J Vet Pharmacol Ther 36, 412–416. https://doi.org/10.1111/jvp.12018
Harper, T.A.M., 2017. Conservative Management of Hip Dysplasia. Veterinary Clinics of North America: Small Animal Practice, Hip Dysplasia 47, 807–821. https://doi.org/10.1016/j.cvsm.2017.02.007
Hechler, A.C., Moore, S.A., 2018. Understanding and Treating Chiari-like Malformation and Syringomyelia in Dogs. Topics in Companion Animal Medicine 33, 1–11. https://doi.org/10.1053/j.tcam.2018.03.002
Henrotin, Y., Sanchez, C., Balligand, M., 2005. Pharmaceutical and nutraceutical management of canine osteoarthritis: Present and future perspectives. The Veterinary Journal 170, 113–123. https://doi.org/10.1016/j.tvjl.2004.08.014
Hernández-Avalos, I., Valverde, A., Ibancovichi-Camarillo, J.A., Sánchez-Aparicio, P., Recillas-Morales, S., Osorio-Avalos, J., Rodríguez-Velázquez, D., Miranda-Cortés, A.E., 2020. Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy. PLoS One 15, e0223697. https://doi.org/10.1371/journal.pone.0223697
Horikirizono, H., Ishigaki, K., Amaha, T., Iizuka, K., Nagumo, T., Tamura, K., Seki, M., Edamura, K., Asano, K., 2019. Inhibition of growth of canine-derived vascular endothelial cells by non-steroidal anti-inflammatory drugs and atrial natriuretic peptide. J Vet Med Sci 81, 776–779. https://doi.org/10.1292/jvms.18-0575
Howard, P.A., Delafontaine, P., 2004. Nonsteroidal Anti-Inflammatory drugs and cardiovascular risk. Journal of the American College of Cardiology 43, 519–525. https://doi.org/10.1016/j.jacc.2003.09.043
Innerå, M., 2013. Cutaneous Vasculitis in Small Animals. Veterinary Clinics of North America: Small Animal Practice, Clinical Dermatology 43, 113–134. https://doi.org/10.1016/j.cvsm.2012.09.011
Ito, S., Okuda-Ashitaka, E., Minami, T., 2001. Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neuroscience Research 41, 299–332. https://doi.org/10.1016/S0168-0102(01)00289-9
Iturriaga, M.P., Paredes, R., Arias, J.I., Torres, C.G., 2017. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett 14, 2198–2206. https://doi.org/10.3892/ol.2017.6400
Johnston, L., Narbe, R., 2012. Preferential accumulation of meloxicam in inflamed synovial joints of dogs. Vet Rec 170, 207. https://doi.org/10.1136/vr.100306
Johnston, S.A., Budsberg, S.C., 1997. Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids for The Management of Canine Osteoarthritis. Veterinary Clinics of North America: Small Animal Practice 27, 841–862. https://doi.org/10.1016/S0195-5616(97)50083-0
Johnston, S.A., McLaughlin, R.M., Budsberg, S.C., 2008. Nonsurgical Management of Osteoarthritis in Dogs. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1449–1470. https://doi.org/10.1016/j.cvsm.2008.08.001
Jones, C.J., Streppa, H.K., Harmon, B.G., Budsberg, S.C., 2002. In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. Am J Vet Res 63, 1527–1531. https://doi.org/10.2460/ajvr.2002.63.1527
Kaka, U., Hui Cheng, C., Meng, G.Y., Fakurazi, S., Kaka, A., Behan, A.A., Ebrahimi, M., 2015. Electroencephalographic changes associated with antinociceptive actions of lidocaine, ketamine, meloxicam, and morphine administration in minimally anaesthetized dogs. Biomed Res Int 2015, 305367. https://doi.org/10.1155/2015/305367
Kay-Mugford, P., Benn, S.J., LaMarre, J., Conlon, P., 2000. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. Am J Vet Res 61, 802–810. https://doi.org/10.2460/ajvr.2000.61.802
Kazakos, G.M., Papazoglou, L.G., Rallis, T., Tsimopoulos, G., Adamama-Moraitou, K., Tea, A., 2005. Effects of meloxicam on the haemostatic profile of dogs undergoing orthopaedic surgery. Vet Rec 157, 444–446. https://doi.org/10.1136/vr.157.15.444
Khan, S.A., McLean, M.K., 2012. Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats. Vet. Clin. North Am. Small Anim. Pract. 42, 289–306, vi–vii. https://doi.org/10.1016/j.cvsm.2012.01.003
Knottenbelt, C., Chambers, G., Gault, E., Argyle, D.J., 2006. The in vitro effects of piroxicam and meloxicam on canine cell lines. J Small Anim Pract 47, 14–20. https://doi.org/10.1111/j.1748-5827.2006.00006.x
Konietschke, U., Teske, E., Jurina, K., Stockhaus, C., 2012. Palliative Intralesional Interleukin-2 Treatment in Dogs with Urinary Bladder and Urethral Carcinomas. In Vivo 26, 931–935.
KuKanich, B., 2013. Outpatient Oral Analgesics in Dogs and Cats Beyond Nonsteroidal Antiinflammatory Drugs: An Evidence-based Approach. Veterinary Clinics of North America: Small Animal Practice, Clinical Pharmacology and Therapeutics 43, 1109–1125. https://doi.org/10.1016/j.cvsm.2013.04.007
KuKanich, B., Bidgood, T., Knesl, O., 2012. Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs. Veterinary Anaesthesia and Analgesia 39, 69–90. https://doi.org/10.1111/j.1467-2995.2011.00675.x
Lamont, L.A., 2008. Adjunctive Analgesic Therapy in Veterinary Medicine. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1187–1203. https://doi.org/10.1016/j.cvsm.2008.06.002
Laredo, F.G., Belda, E., Murciano, J., Escobar, M., Navarro, A., Robinson, K.J., Jones, R.S., 2004. Comparison of the analgesic effects of meloxicam and carprofen administered preoperatively to dogs undergoing orthopaedic surgery. Vet Rec 155, 667–671. https://doi.org/10.1136/vr.155.21.667
Lascelles, B.D.X., Brown, D.C., Conzemius, M.G., Gill, M., Oshinsky, M.L., Sharkey, M., 2019. Measurement of chronic pain in companion animals: Discussions from the Pain in Animals Workshop (PAW) 2017. The Veterinary Journal 250, 71–78. https://doi.org/10.1016/j.tvjl.2019.07.001
Lee, J.L., Mukhtar, H., Bickers, D.R., Kopelovich, L., Athar, M., 2003. Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicology and Applied Pharmacology 192, 294–306. https://doi.org/10.1016/S0041-008X(03)00301-6
Leece, E.A., Brearley, J.C., Harding, E.F., 2005. Comparison of carprofen and meloxicam for 72 hours following ovariohysterectomy in dogs. Vet Anaesth Analg 32, 184–192. https://doi.org/10.1111/j.1467-2995.2005.00207.x
Lees, P., Giraudel, J., Landoni, M.F., Toutain, P.L., 2004. PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther 27, 491–502. https://doi.org/10.1111/j.1365-2885.2004.00618.x
Lemke, K.A., Creighton, C.M., 2010. Analgesia for Anesthetized Patients. Topics in Companion Animal Medicine, Anesthesia Update 25, 70–82. https://doi.org/10.1053/j.tcam.2009.12.003
LeRoy, B.E., Northrup, N., 2009. Prostate cancer in dogs: Comparative and clinical aspects. The Veterinary Journal 180, 149–162. https://doi.org/10.1016/j.tvjl.2008.07.012
Looney, A., 2010. Oncology Pain in Veterinary Patients. Topics in Companion Animal Medicine, Chronic Pain 25, 32–44. https://doi.org/10.1053/j.tcam.2009.10.008
Lorena, S.E.R.S., Luna, S.P.L., Lascelles, B.D.X., Corrente, J.E., 2014. Current attitudes regarding the use of perioperative analgesics in dogs and cats by Brazilian veterinarians. Vet Anaesth Analg 41, 82–89. https://doi.org/10.1111/vaa.12104
Mabry, K., Hill, T., Tolbert, M.K., 2021. Prevalence of gastrointestinal lesions in dogs chronically treated with nonsteroidal anti-inflammatory drugs. J Vet Intern Med. https://doi.org/10.1111/jvim.16057
Marcinowska, A., Warland, J., Brearley, M., Dobson, J., 2013. A novel approach to treatment of lymphangiosarcoma in a boxer dog. J Small Anim Pract 54, 334–337. https://doi.org/10.1111/jsap.12054
Mathews, K.A., 2008a. Neuropathic Pain in Dogs and Cats: If Only They Could Tell Us If They Hurt. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1365–1414. https://doi.org/10.1016/j.cvsm.2008.09.001
Mathews, K.A., 2008b. Pain Management for the Pregnant, Lactating, and Neonatal to Pediatric Cat and Dog. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1291–1308. https://doi.org/10.1016/j.cvsm.2008.07.001
Mathews, K.A., 2000. Nonsteroidal Anti-Inflammatory Analgesics: Indications and Contraindications for Pain Management in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 30, 783–804. https://doi.org/10.1016/S0195-5616(08)70007-X
Mathews, K.A., Pettifer, G., Foster, R., McDonell, W., 2001. Safety and efficacy of preoperative administration of meloxicam, compared with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery. Am J Vet Res 62, 882–888. https://doi.org/10.2460/ajvr.2001.62.882
Matsuyama, A., Schott, C.R., Wood, G.A., Richardson, D., Woods, J.P., Mutsaers, A.J., 2018. Evaluation of metronomic cyclophosphamide chemotherapy as maintenance treatment for dogs with appendicular osteosarcoma following limb amputation and carboplatin chemotherapy. J Am Vet Med Assoc 252, 1377–1383. https://doi.org/10.2460/javma.252.11.1377
McLaughlin, R., 2000. Management of Chronic Osteoarthritic Pain. Veterinary Clinics of North America: Small Animal Practice 30, 933–949. https://doi.org/10.1016/S0195-5616(08)70016-0
McLean, M.K., Khan, S.A., 2018. Toxicology of Frequently Encountered Nonsteroidal Anti-inflammatory Drugs in Dogs and Cats: An Update. Veterinary Clinics of North America: Small Animal Practice, Common Toxicologic Issues in Small Animals: An Update 48, 969–984. https://doi.org/10.1016/j.cvsm.2018.06.003
Meeson, R., Corr, S., 2011. Management of Pelvic Trauma: Neurological damage, urinary tract disruption and pelvic fractures. Journal of Feline Medicine & Surgery 13, 347–361. https://doi.org/10.1016/j.jfms.2011.03.011
Mellett, S., Verganti, S., Murphy, S., Bowlt, K., 2015. Squamous cell carcinoma of the anal sacs in three dogs. Journal of Small Animal Practice 56, 223–225. https://doi.org/10.1111/jsap.12264
Milam, S.B., 2000. Chronic Temporomandibular Joint Arthralgia. Oral and Maxillofacial Surgery Clinics of North America 12, 5–26. https://doi.org/10.1016/S1042-3699(20)30228-4
Monteiro, B., Steagall, P.V., 2019. Antiinflammatory Drugs. Veterinary Clinics of North America: Small Animal Practice, Alternatives to Opioid Analgesia in Small Animal Anesthesia 49, 993–1011. https://doi.org/10.1016/j.cvsm.2019.07.009
Monteiro-Steagall, B.P., Steagall, P.V.M., Lascelles, B.D.X., 2013. Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs. J. Vet. Intern. Med. 27, 1011–1019. https://doi.org/10.1111/jvim.12127
Montoya, L., Ambros, L., Kreil, V., Bonafine, R., Albarellos, G., Hallu, R., Soraci, A., 2004. A pharmacokinetic comparison of meloxicam and ketoprofen following oral administration to healthy dogs. Vet Res Commun 28, 415–428. https://doi.org/10.1023/b:verc.0000034995.81994.49
Moreau, M., Dupuis, J., Bonneau, N.H., Desnoyers, M., 2003. Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Vet Rec 152, 323–329. https://doi.org/10.1136/vr.152.11.323
Morgan, E., O’Connell, K., Thomson, M., Boyd, S., Sandy, J., 2019. Primary Hepatic Neuroendocrine Carcinoma Treated with Doxorubicin and Cyclophosphamide in a Dog. J Am Anim Hosp Assoc 55, e55305. https://doi.org/10.5326/JAAHA-MS-6887
Moses, V.S., Bertone, A.L., 2002. Nonsteroidal anti-inflammatory drugs. Veterinary Clinics of North America: Equine Practice 18, 21–37. https://doi.org/10.1016/S0749-0739(01)00002-5
Mullins, K.B., Thomason, J.M., Lunsford, K.V., Pinchuk, L.M., Langston, V.C., Wills, R.W., McLaughlin, R.M., Mackin, A.J., 2012. Effects of carprofen, meloxicam and deracoxib on platelet function in dogs. Vet Anaesth Analg 39, 206–217. https://doi.org/10.1111/j.1467-2995.2011.00684.x
N, P., Ss, A., Pv, M., 2019. Comprehensive biology of antipyretic pathways. Cytokine 116, 120–127. https://doi.org/10.1016/j.cyto.2019.01.008
Nakagawa, K., Miyagawa, Y., Takemura, N., Hirose, H., 2007. Influence of preemptive analgesia with meloxicam before resection of the unilateral mammary gland on postoperative cardiovascular parameters in dogs. J Vet Med Sci 69, 939–944. https://doi.org/10.1292/jvms.69.939
Nell, T., Bergman, J., Hoeijmakers, M., Van Laar, P., Horspool, L.J.I., 2002. Comparison of vedaprofen and meloxicam in dogs with musculoskeletal pain and inflammation. J Small Anim Pract 43, 208–212. https://doi.org/10.1111/j.1748-5827.2002.tb00059.x
Ng, L.E., Halliwell, B., Wong, K.P., 2008. Nephrotoxic cell death by diclofenac and meloxicam. Biochem Biophys Res Commun 369, 873–877. https://doi.org/10.1016/j.bbrc.2008.02.116
Oh, N., Kim, S., Hosoya, K., Okumura, M., 2014. Compensatory cellular reactions to nonsteroidal anti-inflammatory drugs on osteogenic differentiation in canine bone marrow-derived mesenchymal stem cells. J Vet Med Sci 76, 629–636. https://doi.org/10.1292/jvms.13-0482
Oh, N., Sunaga, T., Yamazaki, H., Hosoya, K., Takagi, S., Okumura, M., 2013. Limited inhibitory effects of non-steroidal antiinflammatory drugs on in vitro osteogenic differentiation in canine cells. Jpn J Vet Res 61, 97–107.
Pacheco, M., Knowles, T.G., Hunt, J., Slingsby, L.S., Taylor, P.M., Murrell, J.C., 2020. Comparing paracetamol/codeine and meloxicam for postoperative analgesia in dogs: a non-inferiority trial. Vet Rec 187, e61. https://doi.org/10.1136/vr.105487
Packeiser, E.-M., Hewicker-Trautwein, M., Thiemeyer, H., Mohr, A., Junginger, J., Schille, J.T., Murua Escobar, H., Nolte, I., 2020. Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis. PLoS One 15, e0230272. https://doi.org/10.1371/journal.pone.0230272
Pang, L.Y., Gatenby, E.L., Kamida, A., Whitelaw, B.A., Hupp, T.R., Argyle, D.J., 2014. Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. PLoS One 9, e83144. https://doi.org/10.1371/journal.pone.0083144
Papich, M.G., 2008. An Update on Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Small Animals. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1243–1266. https://doi.org/10.1016/j.cvsm.2008.09.002
Papich, M.G., 2000. Pharmacologic Considerations for Opiate Analgesic and Nonsteroidal Anti-Inflammatory Drugs. Veterinary Clinics of North America: Small Animal Practice 30, 815–837. https://doi.org/10.1016/S0195-5616(08)70009-3
Pascoe, P.J., 2000. Perioperative Pain Management. Veterinary Clinics of North America: Small Animal Practice 30, 917–932. https://doi.org/10.1016/S0195-5616(08)70015-9
Peterson, K.D., Keefe, T.J., 2004. Effects of meloxicam on severity of lameness and other clinical signs of osteoarthritis in dogs. J Am Vet Med Assoc 225, 1056–1060. https://doi.org/10.2460/javma.2004.225.1056
Poulsen Nautrup, B., Hörstermann, D., 1999. [Pharmacodynamic and pharmacokinetic aspects of the non-inflammatory non-steroidal agent meloxicam in dogs]. Dtsch Tierarztl Wochenschr 106, 94–100.
Punke, J.P., Speas, A.L., Reynolds, L.R., Budsberg, S.C., 2008. Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs. Am J Vet Res 69, 1203–1209. https://doi.org/10.2460/ajvr.69.9.1203
Radi, Z.A., Khan, N.K., 2006. Effects of cyclooxygenase inhibition on the gastrointestinal tract. Experimental and Toxicologic Pathology 58, 163–173. https://doi.org/10.1016/j.etp.2006.06.004
Rainsford, K.D., Skerry, T.M., Chindemi, P., Delaney, K., 1999. Effects of the NSAIDs meloxicam and indomethacin on cartilage proteoglycan synthesis and joint responses to calcium pyrophosphate crystals in dogs. Vet Res Commun 23, 101–113. https://doi.org/10.1023/a:1006254402163
Reed, S., 2002. Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler. Can Vet J 43, 971–972.
Richardson, C.E., Emery, P., 1995. New cyclo-oxygenase and cytokine inhibitors. Baillière’s Clinical Rheumatology, Innovative Treatment Approaches for Rheumatoid Arthritis 9, 731–758. https://doi.org/10.1016/S0950-3579(05)80311-5
Rousse, C.A., Olby, N.J., Williams, K., Harris, T.L., Griffith, E.H., Mariani, C.L., Muñana, K.R., Early, P.J., 2016. Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations. The Veterinary Journal 213, 59–63. https://doi.org/10.1016/j.tvjl.2016.04.002
Ruel, H.L.M., Steagall, P.V., 2019. Adjuvant Analgesics in Acute Pain Management. Veterinary Clinics of North America: Small Animal Practice, Alternatives to Opioid Analgesia in Small Animal Anesthesia 49, 1127–1141. https://doi.org/10.1016/j.cvsm.2019.07.005
Ruel, H.L.M., Watanabe, R., Evangelista, M.C., Beauchamp, G., Auger, J.-P., Segura, M., Steagall, P.V., 2020. Pain burden, sensory profile and inflammatory cytokines of dogs with naturally-occurring neuropathic pain treated with gabapentin alone or with meloxicam. PLoS One 15, e0237121. https://doi.org/10.1371/journal.pone.0237121
Rusbridge, C., Jeffery, N.D., 2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia. The Veterinary Journal 175, 164–172. https://doi.org/10.1016/j.tvjl.2006.12.007
Saito, T., Tamura, D., Asano, R., 2014. Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. Oncol Rep 31, 1637–1644. https://doi.org/10.3892/or.2014.3010
Sanderson, R.O., Beata, C., Flipo, R.-M., Genevois, J.-P., Macias, C., Tacke, S., Vezzoni, A., Innes, J.F., 2009. Systematic review of the management of canine osteoarthritis. Vet Rec 164, 418–424. https://doi.org/10.1136/vr.164.14.418
Sauvé, F., Paradis, M., Refsal, K.R., Moreau, M., Beauchamp, G., Dupuis, J., 2003. Effects of oral administration of meloxicam, carprofen, and a nutraceutical on thyroid function in dogs with osteoarthritis. Can Vet J 44, 474–479.
Scrivani, S.J., Khawaja, S.N., Bavia, P.F., 2018. Nonsurgical Management of Pediatric Temporomandibular Joint Dysfunction. Oral and Maxillofacial Surgery Clinics of North America, Pediatric Temporomandibular Joint Disorders 30, 35–45. https://doi.org/10.1016/j.coms.2017.08.001
Shukla, A.K., Pinard, C.L., Flynn, B.L., Bauman, C.A., 2020. Effects of orally administered gabapentin, tramadol, and meloxicam on ocular variables in healthy dogs. Am J Vet Res 81, 973–984. https://doi.org/10.2460/ajvr.81.12.973
Slovak, J.E., Turbeville, C., Grubb, T., 2020. Assessment of Veterinary Students’ Responses to Questions Regarding Small Animal Pain Recognition and Analgesic Treatment Options. J Vet Med Educ 47, 482–487. https://doi.org/10.3138/jvme.0418-036r3
Smith, B.J., Kirschner, S.M., Kendall, L.V., 2020. Pharmacokinetics of Sustained-release, Oral, and Subcutaneous Meloxicam over 72 Hours in Male Beagle Dogs. J Am Assoc Lab Anim Sci 59, 737–741. https://doi.org/10.30802/AALAS-JAALAS-19-000155
Steinmeyer, J., Konttinen, Y.T., 2006. Oral treatment options for degenerative joint disease—presence and future. Advanced Drug Delivery Reviews, Drug Delivery in Degenerative Joint Disease 58, 168–211. https://doi.org/10.1016/j.addr.2006.01.007
Streppa, H.K., Jones, C.J., Budsberg, S.C., 2002. Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. Am J Vet Res 63, 91–94. https://doi.org/10.2460/ajvr.2002.63.91
Takashima, S., Takitani, S.-I., Kitamura, M., Nishii, N., Kitagawa, H., Shibata, S., 2019. Effect of cyclooxygenase-2 inhibitors at therapeutic doses on body temperature during anesthesia in healthy dogs administered with amino acids. J Vet Med Sci 81, 1379–1384. https://doi.org/10.1292/jvms.17-0098
Teixeira, R.C., Monteiro, E.R., Campagnol, D., Coelho, K., Bressan, T.F., Monteiro, B.S., 2013. Effects of tramadol alone, in combination with meloxicam or dipyrone, on postoperative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy. Vet Anaesth Analg 40, 641–649. https://doi.org/10.1111/vaa.12080
Tomsič, K., Rakinić, K., Sokolov, C., Seliškar, A., 2021. A survey study on the recognition and treatment of pain in dogs and cats by Slovenian veterinarians. Vet Anaesth Analg. https://doi.org/10.1016/j.vaa.2020.11.007
Tsai, T., Chang, S., Chou, P., Yeh, L., 2013. Comparison of postoperative effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy. Veterinary Anaesthesia and Analgesia 40, 615–622. https://doi.org/10.1111/vaa.12064
Viking Höglund, O., Frendin, J., 2002. Analgesic effect of meloxicam in canine acute dermatitis--a pilot study. Acta Vet Scand 43, 247–252. https://doi.org/10.1186/1751-0147-43-247
Waldherr, K., Zurbriggen, A., Spreng, D.E., Forterre, S., 2012. In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells. Am J Vet Res 73, 1752–1758. https://doi.org/10.2460/ajvr.73.11.1752
Wallace, J.L., 2002. Selective cyclooxygenase-2 inhibitors: after the smoke has cleared. Digestive and Liver Disease 34, 89–94. https://doi.org/10.1016/S1590-8658(02)80234-1
Walton, S., Ryan, K.A., Davis, J.L., Acierno, M., 2017. Treatment of meloxicam overdose in a dog via therapeutic plasma exchange. J Vet Emerg Crit Care (San Antonio) 27, 444–450. https://doi.org/10.1111/vec.12607
Webb, A.A., 2003. Potential Sources of Neck and Back Pain in Clinical Conditions of Dogs and Cats: A Review. The Veterinary Journal 165, 193–213. https://doi.org/10.1016/S1090-0233(02)00249-6
Wernham, B.G.J., Trumpatori, B., Hash, J., Lipsett, J., Davidson, G., Wackerow, P., Thomson, A., Lascelles, B.D.X., 2011. Dose Reduction of Meloxicam in Dogs with Osteoarthritis-Associated Pain and Impaired Mobility. Journal of Veterinary Internal Medicine 25, 1298–1305. https://doi.org/10.1111/j.1939-1676.2011.00825.x
White, C., Morrow, L., 2020. Efficacy of meloxicam compared with carprofen for treating canine osteoarthritis. Vet Rec 186, 94. https://doi.org/10.1136/vr.m50
Wolfesberger, B., Hoelzl, C., Walter, I., Reider, G.A., Fertl, G., Thalhammer, J.G., Skalicky, M., Egerbacher, M., 2006. In vitro effects of meloxicam with or without doxorubicin on canine osteosarcoma cells. J Vet Pharmacol Ther 29, 15–23. https://doi.org/10.1111/j.1365-2885.2006.00704.x
Wolfesberger, Birgitt, Walter, I., Hoelzl, C., Thalhammer, J.G., Egerbacher, M., 2006. Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells. Res Vet Sci 80, 308–316. https://doi.org/10.1016/j.rvsc.2005.07.013
Wooten, J.G., Blikslager, A.T., Marks, S.L., Law, J.M., Graeber, E.C., Lascelles, B.D.X., 2009. Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs. Am J Vet Res 70, 1243–1249. https://doi.org/10.2460/ajvr.70.10.1243
WSAVA, 2014. GUIDELINES FOR RECOGNITION, ASSESSMENT AND TREATMENT OF PAIN: WSAVA Global Pain Council. Journal of Small Animal Practice 59.
Wu, G.-H., Shi, H.-J., Che, M.-T., Huang, M.-Y., Wei, Q.-S., Feng, B., Ma, Y.-H., Wang, L.-J., Jiang, B., Wang, Y.-Q., Han, I., Ling, E.-A., Zeng, X., Zeng, Y.-S., 2018. Recovery of paralyzed limb motor function in canine with complete spinal cord injury following implantation of MSC-derived neural network tissue. Biomaterials 181, 15–34. https://doi.org/10.1016/j.biomaterials.2018.07.010
Yamashita, K., Okano, Y., Yamashita, M., Umar, M.A., Kushiro, T., Muir, W.W., 2008. Effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration of sevoflurane in dogs. J Vet Med Sci 70, 29–35. https://doi.org/10.1292/jvms.70.29
Yuan, Y., Chen, X.-Y., Li, S.-M., Wei, X.-Y., Yao, H.-M., Zhong, D.-F., 2009. Pharmacokinetic studies of meloxicam following oral and transdermal administration in Beagle dogs. Acta Pharmacol Sin 30, 1060–1064. https://doi.org/10.1038/aps.2009.73
Zanuzzo, F.S., Teixeira-Neto, F.J., Teixeira, L.R., Diniz, M.S., Souza, V.L., Thomazini, C.M., Steagall, P.V.M., 2015a. Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination in bitches undergoing ovariohysterectomy. The Veterinary Journal 205, 33–37. https://doi.org/10.1016/j.tvjl.2015.05.004
Zanuzzo, F.S., Teixeira-Neto, F.J., Thomazini, C.M., Takahira, R.K., Conner, B., Diniz, M.S., 2015b. Effects of dipyrone, meloxicam, or the combination on hemostasis in conscious dogs. J Vet Emerg Crit Care (San Antonio) 25, 512–520. https://doi.org/10.1111/vec.12336

Expert Opinion

1317822* | 221003 Extrapolation of pharmacological properties in man and veterinary species. Some material employed in collating the data displayed here was taken from veterinary product datasheets or extrapolated from pharmacology texts.

Meloxicam

Acute Pain

Chronic Pain

Perioperative Analgesia

Osteoarthritis

Neoplasia

Fever

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