Select Species Dataset
Acetazolamide
Glaucoma
Suitability: Low | Topical Carbonic Anhydrase Inhibitors (CAls) appear to be more effective in reducing lOP compared to systemic CAIs, have fewer side effects and are presently preferred.
Additional Therapy: Glaucoma requires urgent treatment and medical therapy. This generally includes hyperosmotic agents, e.g. mannitol 1-2g/kg over 20-30 mins as a slow IV infusion, and prostaglandins topically.
Therapeutics
Evidence Base
Gelatt, K.N., Gum, G., Williams, L.W., Gwin, R.M., 1979. Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles. Am J Vet Res 40, 334–345.
Maren, T.H., 1976. The rates of movement of Na+, Cl-, and HCO-3 from plasma to posterior chamber: effect of acetazolamide and relation to the treatment of glaucoma. Invest Ophthalmol 15, 356–364.
Maren, T.H., Haywood, J.R., Chapman, S.K., Zimmerman, T.J., 1977. The pharmacology of methazolamide in relation to the treatment of glaucoma. Invest Ophthalmol Vis Sci 16, 730–742.
Zimmerman, T.J., Garg, L.C., Vogh, B.P., Maren, T.H., 1976. The effect of acetazolamide on the movements of anions into the posterior chamber of the dog eye. J Pharmacol Exp Ther 196, 510–516.