Acetylsalicylic Acid
Anti-Platelet-Aggregation (IMHA)
Therapeutics
Evidence Base
Blois, S.L., Allen, D.G., Wood, R.D., Conlon, P.D., 2010. Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs. American Journal of Veterinary Research 71, 349–358. https://doi.org/10.2460/ajvr.71.3.349
Capurro, N.L., Lipson, L.C., Bonow, R.O., Goldstein, R.E., Shulman, N.R., Epstein, S.E., 1980. Relative effects of aspirin on platelet aggregation and prostaglandin-mediated coronary vasodilatation in the dog. Circulation 62, 1221–1227. https://doi.org/10.1161/01.CIR.62.6.1221
Di Mauro, F.M., Holowaychuk, M.K., 2013. Intravenous administration of desmopressin acetate to reverse acetylsalicylic acid-induced coagulopathy in three dogs. Journal of Veterinary Emergency and Critical Care 23, 455–458. https://doi.org/10.1111/vec.12067
Griebsch, C., Hall, E., Barrs, V.R., 2022. Effectiveness of aspirin vs. clopidogrel in dogs with immune mediated haemolytic anaemia evaluated by serial thromboelastography and platelet mapping. The Veterinary Journal 287, 105882. https://doi.org/10.1016/j.tvjl.2022.105882
Haines, J.M., Lee, P.M., Hegedus, R.M., Hwang, J.K., Court, M.H., 2019a. Investigation into the causes of aspirin resistance in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics 42, 160–170. https://doi.org/10.1111/jvp.12725
Haines, J.M., Lee, P.M., Hegedus, R.M., Hwang, J.K., Court, M.H., 2019b. Investigation into the causes of aspirin resistance in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics 42, 160–170. https://doi.org/10.1111/jvp.12725
Haines, J.M., Lee, P.M., Hegedus, R.M., Hwang, J.K., Court, M.H., 2017. Establishment of reference ranges and evaluation of in vitro concentration-dependent platelet inhibition by acetylsalicylic acid for multiple electrode impedance aggregometry in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics 40, 618–628. https://doi.org/10.1111/jvp.12405
Haines, J.M., Thomason, J.M., Seage, E.C., Wills, R.W., Bulla, C., Lunsford, K.V., Mackin, A.J., 2016. In vitro and in vivo assessment of platelet function in healthy dogs during administration of a low-dose aspirin regimen. Am J Vet Res 77, 174–185. https://doi.org/10.2460/ajvr.77.2.174
Harker, L.A., Fuster, V., 1986. Pharmacology of platelet inhibitors. Journal of the American College of Cardiology, Symposium on Thrombosis and Antithrombotic Therapy—1986 8, 21B-32B. https://doi.org/10.1016/S0735-1097(86)80004-3
McLewee, N., Archer, T., Wills, R., Mackin, A., Thomason, J., 2018. Effects of aspirin dose escalation on platelet function and urinary thromboxane and prostacyclin levels in normal dogs. Journal of Veterinary Pharmacology and Therapeutics 41, 60–67. https://doi.org/10.1111/jvp.12432
Nielsen, L.A., Zois, N.E., Pedersen, H.D., Olsen, L.H., Tarnow, I., 2007. Platelet function in dogs: breed differences and effect of acetylsalicylic acid administration. Veterinary Clinical Pathology 36, 267–273. https://doi.org/10.1111/j.1939-165X.2007.tb00222.x
O’Kell, A.L., Grant, D.C., Panciera, D.L., Troy, G.C., Weinstein, N.M., 2012. Effects of oral prednisone administration with or without ultralow-dose acetylsalicylic acid on coagulation parameters in healthy dogs. American Journal of Veterinary Research 73, 1569–1576. https://doi.org/10.2460/ajvr.73.10.1569
Shropshire, S., Johnson, T., Olver, C., 2020. Platelet aggregometry testing during aspirin or clopidogrel treatment and measurement of clopidogrel metabolite concentrations in dogs with protein-losing nephropathy. J Vet Intern Med 34, 710–718. https://doi.org/10.1111/jvim.15694
Smith, S.A., 2012. Antithrombotic Therapy. Topics in Companion Animal Medicine, Selected Coagulation Diagnostics and Disorders 27, 88–94. https://doi.org/10.1053/j.tcam.2012.08.002
Thomason, J., Archer, T., Wills, R., Press, S., Mackin, A., 2016. The Effects of Cyclosporine and Aspirin on Platelet Function in Normal Dogs. J Vet Intern Med 30, 1022–1030. https://doi.org/10.1111/jvim.13960
Thomason, J.M., Mooney, A.P., Price, J.M., Whittemore, J.C., 2019. Effects of Aspirin and Prednisone on Platelet Function and Thromboxane Synthesis in Healthy Dogs. Front Vet Sci 6, 393. https://doi.org/10.3389/fvets.2019.00393
Weinkle, T.K., Center, S.A., Randolph, J.F., Warner, K.L., Barr, S.C., Erb, H.N., 2005. Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993–2002). Journal of the American Veterinary Medical Association 226, 1869–1880. https://doi.org/10.2460/javma.2005.226.1869
Welter, H., Lauterjung, K.L., Isselhard, W., 1978. [Inhibition of thrombocyte aggregation in hemorrhagic shock using acetylsalicylic acid and mechanical ventilation]. Chir Forum Exp Klin Forsch 89–93.
Westgarth, S., Blois, S.L., D. Wood, R., Verbrugghe, A., Ma, D.W., 2018. Effects of omega-3 polyunsaturated fatty acids and aspirin, alone and combined, on canine platelet function. Journal of Small Animal Practice 59, 272–280. https://doi.org/10.1111/jsap.12776