1. Abelö, A., Eriksson, U.G., Karlsson, M.O., Larsson, H., Gabrielsson, J., 2000. A turnover model of irreversible inhibition of gastric acid secretion by omeprazole in the dog. J Pharmacol Exp Ther 295, 662–669.

2. Bersenas, A.M.E., Mathews, K.A., Allen, D.G., Conlon, P.D., 2005. Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. Am J Vet Res 66, 425–431. https://doi.org/10.2460/ajvr.2005.66.425

3. Brooks, D., Watson, G.L., 1997. Omeprazole in a dog with gastrinoma. J Vet Intern Med 11, 379–381. https://doi.org/10.1111/j.1939-1676.1997.tb00485.x

4. Campbell, V.W., Yamada, T., 1991. Effect of omeprazole on gene expression in canine gastric parietal cells. Am J Physiol 260, G434-439. https://doi.org/10.1152/ajpgi.1991.260.3.G434

5. Carlsson, E., 1989. A review of the effects of long-term acid inhibition in animals. Scand J Gastroenterol Suppl 166, 19–23. https://doi.org/10.3109/00365528909091238

6. Carlsson, E., Larsson, H., Mattsson, H., Ryberg, B., Sundell, G., 1986. Pharmacology and toxicology of omeprazole--with special reference to the effects on the gastric mucosa. Scand J Gastroenterol Suppl 118, 31–38. https://doi.org/10.3109/00365528609090884

7. Chiavarini, M., Barocelli, E., Ballabeni, V., Razzetti, R., Impicciatore, M., 1992. Omeprazole-like compounds on histamine-stimulated acid and peptic secretions in conscious dog and cat. Boll Soc Ital Biol Sper 68, 429–436.

8. Colin-Jones, D., 1994. Safety of omeprazole and lansoprazole. Lancet 343, 1369.

9. Cui, C., Sun, J., Wang, X., Yu, Z., Shi, Y., 2020. Factors Contributing to Drug Release From Enteric-Coated Omeprazole Capsules: An In Vitro and In Vivo Pharmacokinetic Study and IVIVC Evaluation in Beagle Dogs. Dose Response 18, 1559325820908980. https://doi.org/10.1177/1559325820908980

10. Davis, M.S., Willard, M.D., Nelson, S.L., McCullough, S.M., Mandsager, R.E., Roberts, J., Payton, M.E., 2003. Efficacy of omeprazole for the prevention of exercise-induced gastritis in racing Alaskan sled dogs. J Vet Intern Med 17, 163–166. https://doi.org/10.1111/j.1939-1676.2003.tb02428.x

11. Davis, M.S., Williamson, K.K., 2016. Gastritis and Gastric Ulcers in Working Dogs. Front Vet Sci 3, 30. https://doi.org/10.3389/fvets.2016.00030

12. Ekman, L., Hansson, E., Havu, N., Carlsson, E., Lundberg, C., 1985. Toxicological studies on omeprazole. Scand J Gastroenterol Suppl 108, 53–69.

13. Gaier, A., Price, J., Grubb, L., Fitzgerald, S., Tolbert, M.K., 2021. A prospective, randomized, masked, placebo-controlled crossover study for the effect of 10 mg omeprazole capsules on gastric pH in healthy dogs. J Vet Intern Med 35, 887–891. https://doi.org/10.1111/jvim.16061

14. Garcia-Mazcorro, J.F., Suchodolski, J.S., Jones, K.R., Clark-Price, S.C., Dowd, S.E., Minamoto, Y., Markel, M., Steiner, J.M., Dossin, O., 2012. Effect of the proton pump inhibitor omeprazole on the gastrointestinal bacterial microbiota of healthy dogs. FEMS Microbiol Ecol 80, 624–636. https://doi.org/10.1111/j.1574-6941.2012.01331.x

15. Giacinti, J.A., 2016. Ventriculoperitoneal shunt for treatment of hydrocephalus in a French bulldog puppy. Can Vet J 57, 309–312.

16. Girod, M., Allerton, F., Gommeren, K., Tutunaru, A.C., de Marchin, J., Van Soens, I., Ramery, E., Peeters, D., 2016. Evaluation of the effect of oral omeprazole on canine cerebrospinal fluid production: A pilot study. Vet J 209, 119–124. https://doi.org/10.1016/j.tvjl.2015.10.045

17. Girod, M., Allerton, F., Vangrinsven, E., Tutunaru, A.C., de Marchin, J., Gómez-Fernández-Blanco, C., Ruiz-Nuño, A., Wojnicz, A., Farnir, F., Gommeren, K., Peeters, D., 2019. CSF omeprazole concentration and albumin quotient following high dose intravenous omeprazole in dogs. Res Vet Sci 125, 266–271. https://doi.org/10.1016/j.rvsc.2019.07.009

18. Gradner, G., Kaefinger, R., Dupré, G., 2019. Complications associated with ventriculoperitoneal shunts in dogs and cats with idiopathic hydrocephalus: A systematic review. Journal of Veterinary Internal Medicine 33, 403–412. https://doi.org/10.1111/jvim.15422

19. Happonen, I., Linden, J., Westermarck, E., 2000. Effect of triple therapy on eradication of canine gastric helicobacters and gastric disease. J Small Anim Pract 41, 1–6. https://doi.org/10.1111/j.1748-5827.2000.tb03127.x

20. Hoffmann, K.J., 1986. Identification of the main urinary metabolites of omeprazole after an oral dose to rats and dogs. Drug Metab Dispos 14, 341–348.

21. Hoffmann, K.J., Renberg, L., Olovson, S.G., 1986. Comparative metabolic disposition of oral doses of omeprazole in the dog, rat, and mouse. Drug Metab Dispos 14, 336–340.

22. Hughes, S.M., 2006. Canine gastrinoma: a case study and literature review of therapeutic options. N Z Vet J 54, 242–247. https://doi.org/10.1080/00480169.2006.36705

23. Javaheri, S., Corbett, W.S., Simbartl, L.A., Mehta, S., Khosla, A., 1997. Different effects of omeprazole and Sch 28080 on canine cerebrospinal fluid production. Brain Res 754, 321–324. https://doi.org/10.1016/s0006-8993(97)00175-3

24. Jenkins, C.C., DeNovo, R.C., Patton, C.S., Bright, R.M., Rohrbach, B.W., 1991. Comparison of effects of cimetidine and omeprazole on mechanically created gastric ulceration and on aspirin-induced gastritis in dogs. Am J Vet Res 52, 658–661.

25. Jones, K.R., Maddox, C.W., Ridgway, M.D., Clark-Price, S.C., Dossin, O., 2013. Incidence of bacteremia following upper gastrointestinal endoscopy and biopsy in healthy dogs before, during, and after treatment with omeprazole. Am J Vet Res 74, 239–242. https://doi.org/10.2460/ajvr.74.2.239

26. Jones, S.M., Gaier, A., Enomoto, H., Ishii, P., Pilla, R., Price, J., Suchodolski, J., Steiner, J.M., Papich, M.G., Messenger, K., Tolbert, M.K., 2020. The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs. J Vet Intern Med 34, 1886–1893. https://doi.org/10.1111/jvim.15897

27. Katz, L.B., Tobia, A.J., Shriver, D.A., 1987. Effects of ORF 17583, other histamine H2-receptor antagonists and omeprazole on gastric acid secretory states in rats and dogs. J Pharmacol Exp Ther 242, 437–442.

28. Konturek, S.J., Cieszkowski, M., Kwiecień, N., Konturek, J., Tasler, J., Bilski, J., 1984. Effects of omeprazole, a substituted benzimidazole, on gastrointestinal secretions, serum gastrin, and gastric mucosal blood flow in dogs. Gastroenterology 86, 71–77.

29. Kromer, W., Postius, S., Riedel, R., 2000. Animal pharmacology of reversible antagonism of the gastric acid pump, compared to standard antisecretory principles. Pharmacology 60, 179–187. https://doi.org/10.1159/000028367

30. Kuhl, A., Odunayo, A., Price, J., Hecht, S., Marshall, K., Steiner, J., Tolbert, M.K., 2020. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med 34, 678–683. https://doi.org/10.1111/jvim.15718

31. Lagerstedt, E., Spillmann, T., Airas, N., Solano-Gallego, L., Kilpinen, S., 2021. Ménétrier-like disease in a Pointer with concurrent granulomatous gastritis, helicobacteriosis and leishmaniosis: a case report. BMC Vet Res 17, 98. https://doi.org/10.1186/s12917-021-02802-3

32. Larson, G.M., Sullivan, H.W., 1984. Omeprazole, a long-lasting inhibitor of gastric secretion. J Surg Res 36, 503–507. https://doi.org/10.1016/0022-4804(84)90133-1

33. Larsson, H., Carlsson, E., Junggren, U., Olbe, L., Sjöstrand, S.E., Skånberg, I., Sundell, G., 1983. Inhibition of gastric acid secretion by omeprazole in the dog and rat. Gastroenterology 85, 900–907.

34. Larsson, H., Mattson, H., Sundell, G., Carlsson, E., 1985. Animal pharmacodynamics of omeprazole. A survey of its pharmacological properties in vivo. Scand J Gastroenterol Suppl 108, 23–35. https://doi.org/10.3109/00365528509095817

35. Lotti, F., Twedt, D., Warrit, K., Bryan, S., Vaca, C., Krause, L., Fukushima, K., Boscan, P., 2021. Effect of two different pre-anaesthetic omeprazole protocols on gastroesophageal reflux incidence and pH in dogs. J Small Anim Pract. https://doi.org/10.1111/jsap.13328

36. Lu, C., Li, A.P., 2001. Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. Chem Biol Interact 134, 271–281. https://doi.org/10.1016/s0009-2797(01)00162-4

37. McCormack, R., Olley, L., Glanemann, B., Swann, J.W., 2020. Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care. Sci Rep 10, 15727. https://doi.org/10.1038/s41598-020-72950-3

38. Muenster, M., Hoerauf, A., Vieth, M., 2017. Gastro-oesophageal reflux disease in 20 dogs (2012 to 2014). J Small Anim Pract 58, 276–283. https://doi.org/10.1111/jsap.12646

39. Münster, M., Hörauf, A., Lübke-Becker, A., Grest, P., Rütten, M., 2013. Idiopathic esophagopathies resembling gastroesophageal reflux disease in dogs. Tierarztl Prax Ausg K Kleintiere Heimtiere 41, 173–179.

40. Neiger, R., Gaschen, F., Jaggy, A., 2000. Gastric mucosal lesions in dogs with acute intervertebral disc disease: characterization and effects of omeprazole or misoprostol. J Vet Intern Med 14, 33–36. https://doi.org/10.1892/0891-6640(2000)014<0033:gmlidw>2.3.co;2

41. Okabe, S., 1986. [Effects of gastric proton pump inhibitors on gastric secretion and peptic ulcers]. Nihon Yakurigaku Zasshi 87, 351–360. https://doi.org/10.1254/fpj.87.351

42. Panti, A., Bennett, R.C., Corletto, F., Brearley, J., Jeffery, N., Jeffrey, N., Mellanby, R.J., 2009. The effect of omeprazole on oesophageal pH in dogs during anaesthesia. J Small Anim Pract 50, 540–544. https://doi.org/10.1111/j.1748-5827.2009.00818.x

43. Papich, M.G., 1993. Antiulcer therapy. Vet Clin North Am Small Anim Pract 23, 497–512. https://doi.org/10.1016/s0195-5616(93)50301-7

44. Pappas, T.N., Mulvihill, S.J., Goto, Y., Debas, H.T., 1987. Advances in drug therapy for peptic ulcer disease. Arch Surg 122, 447–450. https://doi.org/10.1001/archsurg.1987.01400160073011

45. Parente, N.L., Bari Olivier, N., Refsal, K.R., Johnson, C.A., 2014. Serum concentrations of gastrin after famotidine and omeprazole administration to dogs. J Vet Intern Med 28, 1465–1470. https://doi.org/10.1111/jvim.12408

46. Pelegrini, L.F., Silva, N.F., Campos, O.P.S., Nery, C.C., Silva, F.M., Lemos, R.S., Yamauchi, K.C.I., Amude, A.M., Pelegrini, L.F., Silva, N.F., Campos, O.P.S., Nery, C.C., Silva, F.M., Lemos, R.S., Yamauchi, K.C.I., Amude, A.M., 2019. Medical therapy using omeprazole in 12 hydrocephalic dogs: clinical, diagnostic, and therapeutic findings. Pesquisa Veterinária Brasileira 39, 823–829. https://doi.org/10.1590/1678-5150-pvb-6332

47. Poirier-Guay, M.-P., Bélanger, M.-C., Frank, D., 2014. Star gazing in a dog: atypical manifestation of upper gastrointestinal disease. Can Vet J 55, 1079–1082.

48. Polentarutti, B., Albery, T., Dressman, J., Abrahamsson, B., 2010. Modification of gastric pH in the fasted dog. J Pharm Pharmacol 62, 462–469. https://doi.org/10.1211/jpp.62.04.0008

49. Poncet, C.M., Dupre, G.P., Freiche, V.G., Bouvy, B.M., 2006. Long-term results of upper respiratory syndrome surgery and gastrointestinal tract medical treatment in 51 brachycephalic dogs. J Small Anim Pract 47, 137–142. https://doi.org/10.1111/j.1748-5827.2006.00057.x

50. Regårdh, C.G., Gabrielsson, M., Hoffman, K.J., Löfberg, I., Skånberg, I., 1985. Pharmacokinetics and metabolism of omeprazole in animals and man--an overview. Scand J Gastroenterol Suppl 108, 79–94. https://doi.org/10.3109/00365528509095821

51. Ryberg, B., Mattsson, H., Carlsson, E., 1988. Effects of omeprazole and ranitidine on gastric acid secretion, blood gastrin levels and [3H]-thymidine incorporation in the oxyntic mucosa from dogs and rats. Digestion 39, 91–99. https://doi.org/10.1159/000199611

52. Säfholm, C., Havu, N., Forssell, H., Sundell, G., Mattsson, H., 1994. Effect of 7 years’ daily oral administration of omeprazole to beagle dogs. Digestion 55, 139–147. https://doi.org/10.1159/000201139

53. Satoh, H., Inatomi, N., Nagaya, H., Inada, I., Nohara, A., Nakamura, N., Maki, Y., 1989. Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J Pharmacol Exp Ther 248, 806–815.

54. Seo, D.-H., Lee, J.-B., Hwang, J.-H., Jeong, J.-W., Song, G.-H., Koo, T.-S., Seo, K.-W., 2019. Pharmacokinetics and pharmacodynamics of intravenous esomeprazole at 2 different dosages in dogs. J Vet Intern Med 33, 531–535. https://doi.org/10.1111/jvim.15383

55. Simoens, C., Woussen-Colle, M.C., De Graef, J., 1988. Effect of cimetidine, ranitidine and omeprazole on postprandial gastrin and somatostatin release in conscious dogs. Regul Pept 22, 285–293. https://doi.org/10.1016/0167-0115(88)90041-9

56. Stachura, J., Konturek, S.J., Cieszkowsky, M., Dabroś, W., Zakrzewska, J., Konturek, J., 1983. Comparison of the effect of omeprazole--a substituted benzimidazole--and ranitidine--a potent H2-receptor antagonist--on histamine-induced gastric acid secretion and the ultrastructure of canine parietal cells. Hepatogastroenterology 30, 205–210.

57. Sullivan, L.A., Wakayama, J., Boscan, P.L., Hyatt, D.R., Twedt, D.C., Lappin, M.R., Dargatz, D.A., 2016. The effects of omeprazole therapy on bacterial colonization of the pharynx in healthy dogs. J Vet Emerg Crit Care (San Antonio) 26, 300–304. https://doi.org/10.1111/vec.12432

58. Swann, J.W., Maunder, C.L., Roberts, E., McLauchlan, G., Adamantos, S., 2016. Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom. J Vet Emerg Crit Care (San Antonio) 26, 419–427. https://doi.org/10.1111/vec.12434

59. Thames, B.E., Lovvorn, J., Papich, M.G., Wills, R., Archer, T., Mackin, A., Thomason, J., 2017. The effects of clopidogrel and omeprazole on platelet function in normal dogs. J Vet Pharmacol Ther 40, 130–139. https://doi.org/10.1111/jvp.12340

60. Tolbert, K., Bissett, S., King, A., Davidson, G., Papich, M., Peters, E., Degernes, L., 2011. Efficacy of oral famotidine and 2 omeprazole formulations for the control of intragastric pH in dogs. J Vet Intern Med 25, 47–54. https://doi.org/10.1111/j.1939-1676.2010.0651.x

61. Wallmark, B., 1989. Omeprazole: mode of action and effect on acid secretion in animals. Methods Find Exp Clin Pharmacol 11 Suppl 1, 101–106.

62. Wallmark, B., 1988. Pharmacology of the proton pump. S Afr Med J 74 Suppl, 4–7.

63. Williamson, K.K., Willard, M.D., McKenzie, E.C., Royer, C.M., Payton, M.E., Davis, M.S., 2007. Efficacy of famotidine for the prevention of exercise-induced gastritis in racing Alaskan sled dogs. J Vet Intern Med 21, 924–927. https://doi.org/10.1892/0891-6640(2007)21[924:eofftp]2.0.co;2

64. Williamson, K.K., Willard, M.D., Payton, M.E., Davis, M.S., 2010. Efficacy of omeprazole versus high-dose famotidine for prevention of exercise-induced gastritis in racing Alaskan sled dogs. J Vet Intern Med 24, 285–288. https://doi.org/10.1111/j.1939-1676.2009.0454.x

Expert Opinion

1. 1317822 | 220804: Extrapolation of pharmacological properties in man and veterinary species. Some material employed in collating the data displayed here was taken from veterinary product datasheets or extrapolated from pharmacology texts.