Amikacin

5-30 mg/kg, IV/IM/ SC, q24h

Dosing Interval: Amikacin is a concentration-dependent antimicrobial, and increased efficacy and decreased toxicity are proposed when higher doses are administered less frequently. Where renal sensitivity is a consideration, increase the dosing frequency to q36h or q48h (Matsumoto et al., 1982; Mayers et al., 1991; Staneva et al., 1994).
Hydration: Animals should remain well hydrated through treatment, and intravenous fluids are recommended in debilitated patients where practical.

Therapeutics

Evidence

1 Species-Specific Evidence Review

Akutsu, S., Samura, K., Shimamura, T., Matsumoto, H., Fukushima, Y., Asano, M., Komatsu, H., Matsuzaki, M., 1982. [Toxicological study of amikacin following intravenous drip infusion. 2. Subacute toxicity in dogs after intravenous injection]. Jpn J Antibiot 35, 2069–2099.
Buyniski, J.P., Bierwagen, M.E., 1975. Comparative effects of kanamycin and amikacin on aortic blood pressure, cardiac rate and surface electrocardiogram in the conscious dog. Res Commun Chem Pathol Pharmacol 11, 327–330.
Clark, C.H., 1977. Toxicity of aminoglycoside antibiotics. Mod Vet Pract 58, 594–598.
Gerding, D.N., Kromhout, J.P., Sullivan, J.J., Hall, W.H., 1976. Antibiotic penetrance of ascitic fluid in dogs. Antimicrob Agents Chemother 10, 850–855. https://doi.org/10.1128/AAC.10.5.850
KuKanich, B., Coetzee, J.F., 2008. Comparative pharmacokinetics of amikacin in Greyhound and Beagle dogs. J Vet Pharmacol Ther 31, 102–107. https://doi.org/10.1111/j.1365-2885.2008.00938.x
Ling, G.V., Conzelman, G.M., Franti, C.E., Ruby, A.L., 1981. Urine concentrations of gentamicin, tobramycin, amikacin, and kanamycin after subcutaneous administration to healthy adult dogs. Am J Vet Res 42, 1792–1794.
Nakamura, K., Akutsu, S., Matsumoto, H., Samura, K., Nakata, Y., Asano, M., Hirata, A., Ishikawa, H., Matsuzaki, M., 1982. [Toxicological study of amikacin following intravenous drip infusion. 1. Acute toxicity in rats, rabbits and dogs, and subacute toxicity in rabbits]. Jpn J Antibiot 35, 2048–2067.

2 Condition-Specific Evidence Review

3 Substance-Specific Evidence Review

5.1 UK SPC Links

5.2 Additional Material Consulted

McArthur, S., 2024. Extrapolating pharmacological properties in man and veterinary species. Expert opinions derived from clinical experience, personal communications and the reputable texts listed in 5.2 were employed in data collation.

Monograph Details