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Ivermectin

Grade

Endectocide | Demodicosis

Therapeutics

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Evidence

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Canine Ivermectin | Literature Review

  1. Al-Azzam, S.I., Fleckenstein, L., Cheng, K.-J., Dzimianski, M.T., McCall, J.W., 2007. Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Biopharmaceutics & Drug Disposition 28, 431–438. https://doi.org/10.1002/bdd.572

  2. Anderson, D.L., Roberson, E.L., 1982. Activity of ivermectin against canine intestinal helminths. Am J Vet Res 43, 1681–1683.

  3. Bates, N., Chatterton, J., Robbins, C., Wells, K., Hughes, J., Stone, M., Campbell, A., 2013. Lipid infusion in the management of poisoning: a report of 6 canine cases. Veterinary Record 172, 339–339. https://doi.org/10.1136/vr.101036

  4. Bauer, C., Bahnemann, R., 1996. Control of Filaroides hirthi infections in Beagle dogs by ivermectin. Veterinary Parasitology 65, 269–273. https://doi.org/10.1016/S0304-4017(96)00976-4

  5. Becker, M.D., Young, B.C., 2017. Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014). VMRR 8, 77–85. https://doi.org/10.2147/VMRR.S129576

  6. Behera, S.K., Dimri, U., Singh, S.K., Mohanta, R.K., 2011. The curative and antioxidative efficiency of ivermectin and ivermectin + vitamin E-selenium treatment on canine Sarcoptes scabiei infestation. Vet Res Commun 35, 237–244. https://doi.org/10.1007/s11259-011-9468-8

  7. Bissonnette, S., Paradis, M., Daneau, I., Silversides, D.W., 2009. The ABCB1-1Delta mutation is not responsible for subchronic neurotoxicity seen in dogs of non-collie breeds following macrocyclic lactone treatment for generalized demodicosis. Vet Dermatol 20, 60–66. https://doi.org/10.1111/j.1365-3164.2008.00731.x

  8. Clarke, D.L., Lee, J.A., Murphy, L.A., Reineke, E.L., 2011. Use of intravenous lipid emulsion to treat ivermectin toxicosis in a Border Collie. Journal of the American Veterinary Medical Association 239, 1328–1333. https://doi.org/10.2460/javma.239.10.1328

  9. Diao, H., Cheng, N., Zhao, Y., Xu, H., Dong, H., Thamm, D.H., Zhang, D., Lin, D., 2019. Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling. BMC Vet Res 15, 276. https://doi.org/10.1186/s12917-019-2026-2

  10. Edwards, G., 2003. Ivermectin: does P-glycoprotein play a role in neurotoxicity? Filaria J 2, S8. https://doi.org/10.1186/1475-2883-2-S1-S8

  11. Epstein, S.E., Hollingsworth, S.R., 2013. Ivermectin-induced blindness treated with intravenous lipid therapy in a dog. Journal of Veterinary Emergency and Critical Care 23, 58–62. https://doi.org/10.1111/vec.12016

  12. Fernandez, A.L., Lee, J.A., Rahilly, L., Hovda, L., Brutlag, A.G., Engebretsen, K., 2011. The use of intravenous lipid emulsion as an antidote in veterinary toxicology. J Vet Emerg Crit Care (San Antonio) 21, 309–320. https://doi.org/10.1111/j.1476-4431.2011.00657.x

  13. Ferreira Bulhosa, L., Estrela-Lima, A., da Silva Solcà, M., Diniz Gonçalves, G.S., Larangeira, D.F., de Pinho, F.A., Barrouin-Melo, S.M., 2020. Vincristine and ivermectin combination chemotherapy in dogs with natural transmissible venereal tumor of different cyto-morphological patterns: A prospective outcome evaluation. Anim Reprod Sci 216, 106358. https://doi.org/10.1016/j.anireprosci.2020.106358

  14. Fudge, M., Jeong, S., McInturff, P., 2007. A clinical trial of ivermectin against eyeworms in German Shepherd military working dogs. US Army Med Dep J 51–56.

  15. González Canga, A., Sahagún Prieto, A.M., José Diez Liébana, M., Martínez, N.F., Vega, M.S., Vieitez, J.J.G., 2009. The pharmacokinetics and metabolism of ivermectin in domestic animal species. The Veterinary Journal 179, 25–37. https://doi.org/10.1016/j.tvjl.2007.07.011

  16. Grandi, G., Quintavalla, C., Mavropoulou, A., Genchi, M., Gnudi, G., Bertoni, G., Kramer, L., 2010. A combination of doxycycline and ivermectin is adulticidal in dogs with naturally acquired heartworm disease (Dirofilaria immitis). Veterinary Parasitology 169, 347–351. https://doi.org/10.1016/j.vetpar.2010.01.025

  17. Gwaltney-Brant, S., Meadows, I., 2012. Use of Intravenous Lipid Emulsions for Treating Certain Poisoning Cases in Small Animals. Veterinary Clinics of North America: Small Animal Practice, Common Toxicologic Issues in Small Animals 42, 251–262. https://doi.org/10.1016/j.cvsm.2011.12.001

  18. Hugnet, C., Bentjen, S.A., Mealey, K.L., 2004. Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of collies from France. Journal of Veterinary Pharmacology and Therapeutics 27, 227–229. https://doi.org/10.1111/j.1365-2885.2004.00585.x

  19. Kuznetsova, E., Bettenay, S., Nikolaeva, L., Majzoub, M., Mueller, R., 2012. Influence of systemic antibiotics on the treatment of dogs with generalized demodicosis. Vet Parasitol 188, 148–155. https://doi.org/10.1016/j.vetpar.2012.02.023

  20. Martin, M.W.S., Ashton, G., Simpson, V.R., Neal, C., 1993. Angiostroneylosis in Cornwall: Clinical presentations of eight cases. Journal of Small Animal Practice 34, 20–25. https://doi.org/10.1111/j.1748-5827.1993.tb02570.x

  21. Mealey, K.L., 2013. Adverse Drug Reactions in Veterinary Patients Associated with Drug Transporters. Veterinary Clinics of North America: Small Animal Practice, Clinical Pharmacology and Therapeutics 43, 1067–1078. https://doi.org/10.1016/j.cvsm.2013.04.004

  22. Mealey, K.L., Bentjen, S.A., Gay, J.M., Cantor, G.H., 2001. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics and Genomics 11, 727–733.

  23. Mealey, K.L., Bentjen, S.A., Waiting, D.K., 2002. Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States. Am J Vet Res 63, 479–481. https://doi.org/10.2460/ajvr.2002.63.479

  24. Merola, V., Khan, S., Gwaltney-Brant, S., 2009. Ivermectin toxicosis in dogs: a retrospective study. J Am Anim Hosp Assoc 45, 106–111. https://doi.org/10.5326/0450106

  25. Suderman, M.T., Craig, T.M., 1984. Efficacy of ivermectin against Dirofilaria immitis microfilariae in naturally infected dogs. Am J Vet Res 45, 1031–1032.

  26. Tada, Y., n.d. Prophylactic activity of ivermectin against Dirofilaria immitis infection in dogs : Establishment of effective dose and administration schedule.

  27. Tranquilli, W.J., Paul, A.J., Seward, R.L., 1989. Ivermectin plasma concentrations in collies sensitive to ivermectin-induced toxicosis. Am J Vet Res 50, 769–770.

  28. Wright, H.M., Chen, A.V., Talcott, P.A., Poppenga, R.H., Mealey, K.L., 2011. Intravenous fat emulsion as treatment for ivermectin toxicosis in three dogs homozygous for the ABCB1-1Δ gene mutation. J Vet Emerg Crit Care (San Antonio) 21, 666–672. https://doi.org/10.1111/j.1476-4431.2011.00687.x

Expert Opinion

  1. 1317822* |  221003 Extrapolation of pharmacological properties in man and veterinary species. Some material employed in collating the data displayed here was taken from veterinary product datasheets or extrapolated from pharmacology texts.


Last Updated by 1317822 | On 221003

Monograph Details

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