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Osteoarthritic Pain [OA]

1. Boileau, C., Martel‐Pelletier, J., Brunet, J., Tardif, G., Schrier, D., Flory, C., El‐Kattan, A., Boily, M., Pelletier, J.-P., 2005. Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. Arthritis & Rheumatism 52, 488–500. https://doi.org/10.1002/art.20809

2. Brioschi, F.A., Di Cesare, F., Gioeni, D., Rabbogliatti, V., Ferrari, F., D’Urso, E.S., Amari, M., Ravasio, G., 2020. Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis. Animals (Basel) 10, 1505. https://doi.org/10.3390/ani10091505

3. Bruecker, K.A., Benjamino, K., Vezzoni, A., Walls, C., Wendelburg, K.L., Follette, C.M., Déjardin, L.M., Guillou, R., 2021. Canine Elbow Dysplasia: Medial Compartment Disease and Osteoarthritis. Veterinary Clinics of North America: Small Animal Practice, Forelimb Lameness 51, 475–515. https://doi.org/10.1016/j.cvsm.2020.12.008

4. Fox, S.M., 2012. Painful Decisions for Senior Pets. Veterinary Clinics of North America: Small Animal Practice, Geriatrics 42, 727–748. https://doi.org/10.1016/j.cvsm.2012.04.010

5. Harper, T.A.M., 2017. Conservative Management of Hip Dysplasia. Veterinary Clinics of North America: Small Animal Practice, Hip Dysplasia 47, 807–821. https://doi.org/10.1016/j.cvsm.2017.02.007

6. Hellyer, P., Rodan, I., Brunt, J., Downing, R., Hagedorn, J., Robertson, S., 2007. AAHA/AAFP pain management guidelines for dogs and cats. Journal of Feline Medicine & Surgery 9, 466–480. https://doi.org/10.1016/j.jfms.2007.09.001

7. Johnston, S.A., McLaughlin, R.M., Budsberg, S.C., 2008. Nonsurgical Management of Osteoarthritis in Dogs. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1449–1470. https://doi.org/10.1016/j.cvsm.2008.08.001

8. KuKanich, B., 2013. Outpatient Oral Analgesics in Dogs and Cats Beyond Nonsteroidal Antiinflammatory Drugs: An Evidence-based Approach. Veterinary Clinics of North America: Small Animal Practice, Clinical Pharmacology and Therapeutics 43, 1109–1125. https://doi.org/10.1016/j.cvsm.2013.04.007

9. Lamont, L.A., 2008. Adjunctive Analgesic Therapy in Veterinary Medicine. Veterinary Clinics of North America: Small Animal Practice, Update on Pain Management 38, 1187–1203. https://doi.org/10.1016/j.cvsm.2008.06.002

10. Mathews, K., Kronen, P.W., Lascelles, D., Nolan, A., Robertson, S., Steagall, P.V., Wright, B., Yamashita, K., 2014. Guidelines for Recognition, Assessment and Treatment of Pain. Journal of Small Animal Practice 55, E10–E68. https://doi.org/10.1111/jsap.12200

11. O’Neill, D.G., Brodbelt, D.C., Hodge, R., Church, D.B., Meeson, R.L., 2020. Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK. Canine Med Genet 7, 1. https://doi.org/10.1186/s40575-020-0080-5

12. Ruel, H.L.M., Steagall, P.V., 2019. Adjuvant Analgesics in Acute Pain Management. Veterinary Clinics of North America: Small Animal Practice, Alternatives to Opioid Analgesia in Small Animal Anesthesia 49, 1127–1141. https://doi.org/10.1016/j.cvsm.2019.07.005

13. Rychel, J.K., 2010. Diagnosis and Treatment of Osteoarthritis. Topics in Companion Animal Medicine, Chronic Pain 25, 20–25. https://doi.org/10.1053/j.tcam.2009.10.005

14. Tryfonidou, M.A., de Vries, G., Hennink, W.E., Creemers, L.B., 2020. “Old Drugs, New Tricks” – Local controlled drug release systems for treatment of degenerative joint disease. Advanced Drug Delivery Reviews 160, 170–185. https://doi.org/10.1016/j.addr.2020.10.012

Gabapentin | Supplementary Literature

1. Gabapentin 300mg Capsules |  SPC | Accessesed 02/01/23: Online Version | https://www.medicines.org.uk/emc/product/4636/smpc Print Version | https://www.medicines.org.uk/emc/product/4636/smpc/print

2. Gabapentin Glenmark 50 mg/ml Oral Solution | SPC |  Accessesed 02/01/23: Online Version: https://www.medicines.org.uk/emc/product/12121 | Print version: (https://www.medicines.org.uk/emc/product/12121/smpc/print)

Gabapentin | Expert Opinion

1. 1317822* |  220805 | Canine: Extrapolation of pharmacological properties in man and veterinary species. Some material employed in collating the data displayed here was taken from veterinary product datasheets or extrapolated from pharmacology texts.